My name is Edward Emmott and I am a postdoc in Nikolai Slavovs lab at Northeastern University. My current work involves studying specialized ribosomes, and the interaction of the immune system with protein synthesis. I am also involved in the lab’s efforts to further develop and apply single cell proteomics (SCoPE-MS). My past work has involved researching positive-sense RNA viruses – most recently norovirus, the cause of ‘winter vomiting disease’.

I’m interested in how viruses replicate and interact with their host, as well as how host cells defend against and adapt to viral infection. By understanding these processes, we can identify new drug targets, or use this information to design vaccines.

For more details please see about me, or my publications.

Preprint: SCoPE2 – next generation single-cell proteomics

Just in time for SCP2019, we have a new preprint led by Harrison Specht released on bioRxiv titled ‘High-throughput single-cell proteomics reveals the emergence of macrophage heterogeneity’. In this manuscript we describe the various sample processing and computational advances that have come together to form our next-generation method for single-cellRead More →

SCP2018 Attendees

Single-cell proteomics 2019 (#SCP2019): 10-12 June

Its not long until SCP2019 begins at Northeastern University in Boston, featuring talks from a range of international speakers on single-cell and low abundance proteomics, and single-cell studies. As part of SCP2019, Ed, along with others from the Slavov lab will be delivering a workshop on how to perform theRead More →

Approaches for Studying Ribosome Specialization published!

Together with Marko Jovanovic and Nikolai Slavov, Ed was invited to contribute to Trends in Biochemical Sciences new ‘Technology of the Month’ format, now  published in TiBS. This article provides an outline of some of the mass spectrometry-based and sequencing approaches to study ribosome specialization and is a companion toRead More →

Norovirus protease precursor manuscript published!

Ed’s last first-author manuscript from his time in the Goodfellow lab: ‘Polyprotein processing and intermolecular interactions within the viral replication complex spatially and temporally control norovirus protease activity’,  is now accepted in the Journal of Biological Chemistry. In it, we looked at the roles of different forms of the norovirusRead More →

Specialized ribosome review published!

Ed has a new first author review – ‘Ribosome heterogeneity: from form to function‘ published with co-authors Marko Jovanovic (Columbia U.) and Nikolai Slavov in Trends in Biochemical Sciences. In it we review the evidence in favor of the existence of functionally specialized ribosomes, and discuss the approaches and testsRead More →

Tandem Mass Tag Research Award!

Ed was awarded one of four Tandem Mass Tag Research awards. These are an annual international award by Thermo Scientific given on the basis of ‘innovative and impactful’ research in Proteomics. Ed will be using his TMT research award to further the development of single cell Proteomics (SCoPE-MS). Thermo TMTRead More →