My name is Edward Emmott and I am a postdoc in Nikolai Slavovs lab at Northeastern University. My current work involves studying specialized ribosomes, and the interaction of the immune system with protein synthesis. I am also involved in the lab’s efforts to further develop and apply single cell proteomics (SCoPE-MS). My past work has involved researching positive-sense RNA viruses – most recently norovirus, the cause of ‘winter vomiting disease’.

I’m interested in how viruses replicate and interact with their host, as well as how host cells defend against and adapt to viral infection. By understanding these processes, we can identify new drug targets, or use this information to design vaccines.

For more details please see about me, or my publications.

Approaches for Studying Ribosome Specialization published!

Together with Marko Jovanovic and Nikolai Slavov, Ed was invited to contribute to Trends in Biochemical Sciences new ‘Technology of the Month’ format, now  published in TiBS. This article provides an outline of some of the mass spectrometry-based and sequencing approaches to study ribosome specialization and is a companion toRead More →

Norovirus protease precursor manuscript published!

Ed’s last first-author manuscript from his time in the Goodfellow lab: ‘Polyprotein processing and intermolecular interactions within the viral replication complex spatially and temporally control norovirus protease activity’,  is now accepted in the Journal of Biological Chemistry. In it, we looked at the roles of different forms of the norovirusRead More →

Specialized ribosome review published!

Ed has a new first author review – ‘Ribosome heterogeneity: from form to function‘ published with co-authors Marko Jovanovic (Columbia U.) and Nikolai Slavov in Trends in Biochemical Sciences. In it we review the evidence in favor of the existence of functionally specialized ribosomes, and discuss the approaches and testsRead More →

Correspondence – Preprints: Good for Science and Public

Together with 8 other eLife Ambassadors, Ed published a correspondence in Nature in response to an earlier article suggesting that preprints are problematic for scientific reporting. We argued that if standard journalistic practices are followed, preprints are no more problematic to report on than peer-reviewed articles. Our correspondence came outRead More →

Preprint – Automated sample preparation for high-throughput single cell proteomics

Our new preprint from first author Harrison Specht is now out on bioRxiv. In it we show a new cleanup-free method for mass spectrometry sample preparation, that makes single cell proteomics higher throughput, more robust, more reproducible and significantly cheaper and compatible with common and affordable lab equipment.   bioRxivRead More →

Tandem Mass Tag Research Award!

Ed was awarded one of four Tandem Mass Tag Research awards. These are an annual international award by Thermo Scientific given on the basis of ‘innovative and impactful’ research in Proteomics. Ed will be using his TMT research award to further the development of single cell Proteomics (SCoPE-MS). Thermo TMTRead More →